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2023

Singer, Julian A. and Stramm, Till and Fasel, Jens and Schween, Oliver and Gelaeschus, Anton and Bahr, Andreas and Kuhl, Matthias

Flexible Polymer Optical Waveguides for Integrated Optogenetic Brain Implants

In Tagungsband "2023 IEEE 36th International Conference on Micro Electro Mechanical Systems Conference (MEMS)", 2023
2023 IEEE 36th International Conference on Micro Electro Mechanical Systems Conference (MEMS)

Abstract:
This paper presents a manufacturing process for flexible optical waveguides made of biocompatible polydimethylsiloxane (PDMS) to be attached to future optogenetic implants. Based on a complementary metal-oxide-semiconductor (CMOS) application-specific integrated circuit (ASIC), the system uses integrated single photon avalanche diodes (SPADs) as sensors for fluorescence imaging (FI) and post-CMOS micro light-emitting diodes (µLEDs) for stimulation [1]. Attaching fibers to SPADs and µLEDs to collect and distribute light from and to deeper brain layers can unfold previously unachieved medical applications. Two technologies for biocompatible waveguide manufacturing are presented: thin-film and molding. Such a combination of integrated bidirectional implantable ASICs with custom waveguide manufacturing is not limited to medical scenarios but opens up a broad field of applications.

BibTeX:
@inproceedings{mems23singer,
author = {Singer and Julian A. and Stramm and Till and Fasel and Jens and Schween and Oliver and Gelaeschus and Anton and Bahr and Andreas and Kuhl and Matthias},
title = {{F}lexible {P}olymer {O}ptical {W}aveguides for {I}ntegrated {O}ptogenetic {B}rain {I}mplants},
year = {2023},
booktitle = {2023 IEEE 36th International Conference on Micro Electro Mechanical Systems Conference (MEMS)},
note = {2023 IEEE 36th International Conference on Micro Electro Mechanical Systems Conference (MEMS)} }

[Abstract] [BibTeX]

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2022

Barth, Tobias and Münch, Matthias and Seide, Klaus and Adam, Christian and Krautschneider, Wolfgang and Schulz, Arndt-Peter

Additive manufactured versus traditional osteosynthesis plates - a finite element analysis

Artikel in "Transactions on Additive Manufacturing Meets Medicine", vol. 4, Nr. 1, p. 644--644, 2022
Number: 1

Abstract:
Additive Manufacturing (AM) is rapidly gaining acceptance in healthcare. Due to 3D printing of polyetheretherketone (PEEK) constructions almost any complex geometry, e. g. bio-mimicking implants or light-weight hollow implant bodies, can be produced. In this paper a direct comparison between PEEK and titanium osteosynthesis plates is achieved with a finite element analysis. By that, pros and cons of PEEK as implant material are discussed and different use cases are identified. For the comparison a generic osteosynthesis plate for diaphysis is designed. The exceeding of the yield strength even at low bending and torsional loads highlights the problems that occur when applying PEEK implants at locations which are affected by moderate mechanical loads. Since fracture stabilisation is the main function of osteosynthesis plates, stiffness is a highly relevant property of these. Therefore, a direct exchange of titanium to PEEK would increase the risk of non-union. Thus, a different structure or an improved material, e. g. carbon fibre PEEK composite, is required for loaded locations to replace metallic implants.

BibTeX:
@article{barth:additive:2022,
author = {Barth and Tobias and M{\"u}nch and Matthias and Seide and Klaus and Adam and Christian and Krautschneider and Wolfgang and Schulz and Arndt-Peter},
title = {{A}dditive manufactured versus traditional osteosynthesis plates - a finite element analysis},
year = {2022},
month = {09},
journal = {Transactions on Additive Manufacturing Meets Medicine},
note = {Number: 1},
number = {1},
pages = {644--644},
volume = {4} }

[Abstract] [BibTeX] [DOI]
Patrick Kleinschnittger, Andreas Bahr, Wolfang Krautschneider

Anregungsimpulsbasierte Impedanzspektroskopie alkalischer und erdalkalischer Lösungen

aug 2022
Beim Biosignale Workshop 2022

Abstract:
Die Impedanzspektroskopie ermöglicht interessante Anwendungen bei der Analyse von biologischem Material. Da bei einer Messung die Superposition aller die Impedanz beeinflussenden Effekte gemessen wird, ist die Interpretation der Messergebnisse häufig sehr schwierig, eine Untersuchung einzelner Bestandteile einer Probe nur bedingt möglich. Eine mögliche Lösung dieses Problems stellt die anregungsimpulsbasierte Impedanzspektroskopie dar. Bei diesem neuen Messverfahren wird ein monophasischer Rechteckpotentialimpuls an die Probe angelegt und die Stromantwort des Systems gemessen. In dieser Arbeit werden vier verschiedene Ionenlösungen verglichen. Basierend auf dem Relaxationsverhalten der Lösungen kann zwischen alkalischen und erdalkalischen Lösungen unterschieden werden.

BibTeX:
@misc{Kleinschnittger:Impedanz:2022,
author = {Patrick Kleinschnittger and Andreas Bahr and Wolfang Krautschneider},
title = {{A}nregungsimpulsbasierte {I}mpedanzspektroskopie alkalischer und erdalkalischer {L}{\"o}sungen},
year = {2022},
month = {08},
howpublished = {Workshop Beitrag},
note = {Beim Biosignale Workshop 2022} }

[Abstract] [BibTeX]
Nico Hinz, Julius Dehoust, Matthias Münch, Klaus Seide, Tobias Barth, Arndt Peter Schulz, Karl-Heinz Frosch, Maximilian Hartel

Biomechanical analysis of fixation methods in acetabular fractures : a systematic review of test setups

Artikel in "European Journal of Trauma and Emergency Surgery", vol. 48, p. 3541-3560, 2022

Abstract:

BibTeX:
@article{Barth:Fracturefixation:2022,
author = {Nico Hinz and Julius Dehoust and Matthias M{\"u}nch and Klaus Seide and Tobias Barth and Arndt Peter Schulz and Karl-Heinz Frosch and Maximilian Hartel},
title = {{B}iomechanical analysis of fixation methods in acetabular fractures : a systematic review of test setups},
year = {2022},
month = {03},
journal = {European Journal of Trauma and Emergency Surgery},
pages = {3541-3560},
volume = {48} }

[BibTeX] [DOI]
Lukas Rennpferdt, Patrick Kleinschnittger, Andreas Bahr, Hoc Khiem Trieu

3D printed silicone spinal cord implant withsub-millimeter feature size

Artikel in "Transactions on Additive Manufacturing Meets Medicine", vol. 4, Nr. 1, 2022

Abstract:
Spinal cord injury (SCI) can lead to the dysfunction of nerve fibers by hemi- or complete transection, resulting in permanent paraplegia. In recent years, a number of therapies have been developed to treat spinal cord injury. A mechanical microconnector system (mMS) that supports the regeneration of nerve fibers after SCI through a combination of different therapies was designed in previous works. For this implantable mMS with minimum feature size of a few hundreds of micrometers, it is essential to provide fast, flexible, three-dimensional fabrication. This paper describes a new fabrication method of the mMS made of silicone using additive manufacturing based on a commercially available material jetting printer. The application of this technology advances the fabrication and adaptability of mMS in terms of higher elasticity of the implant using silicone and additionally with respect to high customizability and rapid prototyping using additive manufacturing. We show the successful adaption and realization of a silicone-based mMS dimensioned for a human model with structure sizes down to 300 μm. We elaborate the advantages and disadvantages of additive, silicone-based 3D printing for this application in comparison to molding-based and subtractive 3D printing methods, thus demonstrating the relevance of this technology for medical application.

BibTeX:
@article{Rennpferdt:3D-Druck:2022,
author = {Lukas Rennpferdt and Patrick Kleinschnittger and Andreas Bahr and Hoc Khiem Trieu},
title = {3{D} printed silicone spinal cord implant withsub-millimeter feature size},
year = {2022},
journal = {Transactions on Additive Manufacturing Meets Medicine},
number = {1},
volume = {4} }

[Abstract] [BibTeX] [DOI]

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2021

Adam, Christian and Barth, Tobias and Münch, Matthias and Seide, Klaus and Krautschneider, Wolfgang H.

An Electronic Osteosynthesis Implant for Continuous Load Monitoring using a Strain Gauge

In Tagungsband "2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)", 2021, p. 01-06
2021 IEEE Biomedical Circuits and Systems Conference (BioCAS), Berlin, 7.-9. October 2021

Abstract:
The utilization of strain gauges for monitoring the applied mechanical load to osteosynthesis plates using electronic implants was reported several times in literature. The technique was found to provide valuable information for monitoring the fracture healing process and for improving the rehabilitation. This paper introduces a new electronic osteosynthesis implant, which uses supercapacitors as an energy storage for short term autonomous operation. Moreover, a bluetooth low energy (BLE) transceiver is integrated into the system, which covers larger distances and is less sensitive to misalignment than the commonly used inductive data transmission. This improves the usability of the proposed system for the patients. The system can continuously sample and transmit strain values at a sampling rate of 5 Hz for more than 10 min without being recharged. More than 60 cm of distance in any practically relevant direction can be covered by the BLE data transmission if the implant is placed 5 cm deep in a phantom. The implant dimensions of 20 mm x 16 mm still fit on osteosynthesis plates for larger bones.

BibTeX:
@inproceedings{Adam:Osteosynthesis:2021,
author = {Adam and Christian and Barth and Tobias and M{\"u}nch and Matthias and Seide and Klaus and Krautschneider and Wolfgang H.},
title = {{A}n {E}lectronic {O}steosynthesis {I}mplant for {C}ontinuous {L}oad {M}onitoring using a {S}train {G}auge},
year = {2021},
month = {10},
booktitle = {2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)},
note = {2021 IEEE Biomedical Circuits and Systems Conference (BioCAS), Berlin, 7.-9. October 2021},
pages = {01-06} }

[Abstract] [BibTeX] [DOI]
Faragalla, Mohamed and Krautschneider, Wolfgang and Kuhl, Matthias

Low-Leakage Differential-Drive Rectifier as 13.56 MHz Inductive Energy Harvester for Deep Medical Implants with Field Exposure Compliance

In Tagungsband "2021 IEEE International Symposium on Circuits and Systems (ISCAS)", 2021, p. 1-5
Korea, 22-28 May 2021

Abstract:
In this paper, we present a 13.56 MHz energy harvester for arterial pressure measurement implants placed at deep distances in human bodies. A 50 Î¼m diameter thin wire is used to fabricate a 150-turn solenoid coil around a PCB stripe with a cross-sectional area of 1.35 Ï‡ 1 mm². The solenoid has a length of 12 mm, low-frequency inductance of 4.75 Î¼Î—, and series resistance of 8 Î©. With this coil and an 11-stage modified differential-drive rectifier, our harvester achieved 698 nW (-31.56 dBm) sensitivity for unloaded output voltage of 1.88 V and maximum receiver efficiency of >72% at -23.5 dBm available power using 0.0228 mm² silicon area in 180 nm technology. A transmission distance of 21 cm was reached under compliance with the field exposure levels set by the IEEE Std. C95.1-2019.

BibTeX:
@inproceedings{9401629,
author = {Faragalla and Mohamed and Krautschneider and Wolfgang and Kuhl and Matthias},
title = {{L}ow-{L}eakage {D}ifferential-{D}rive {R}ectifier as 13.56 {M}{H}z {I}nductive {E}nergy {H}arvester for {D}eep {M}edical {I}mplants with {F}ield {E}xposure {C}ompliance},
year = {2021},
month = {05},
booktitle = {2021 IEEE International Symposium on Circuits and Systems (ISCAS)},
note = {Korea, 22-28 May 2021},
pages = {1-5} }

[Abstract] [BibTeX] [DOI]
Singer, Julian A. and Gelaeschus, Anton and Schuster, Christian and Trieu, Hoc Khiem and Kuhl, Matthias

Integrierte optoelektronische Systeme basierend auf hochempfindlichen Einzelphotonendetektoren für optogenetische Anwendungen

In Tagungsband "Mikroelektronik, Mikrosystemtechnik und ihre Anwendungen - Innovative Produkte fÃ¼r zukunftsfahige Markte - MikroSystemTechnik Congress 2021", 2021, p. 212--215
MST Kongress 2021

Abstract:

BibTeX:
@inproceedings{mst21singer,
author = {Singer and Julian A. and Gelaeschus and Anton and Schuster and Christian and Trieu and Hoc Khiem and Kuhl and Matthias},
title = {{I}ntegrierte optoelektronische {S}ysteme basierend auf hochempfindlichen {E}inzelphotonendetektoren f{\"u}r optogenetische {A}nwendungen},
year = {2021},
booktitle = {Mikroelektronik, Mikrosystemtechnik und ihre Anwendungen - Innovative Produkte fÃ¼r zukunftsfahige Markte - MikroSystemTechnik Congress 2021},
note = {MST Kongress 2021},
pages = {212--215} }

[BibTeX]

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2020

Kuhl, Juliane and Mendoza Ponce, Pablo Daniel and Krautschneider, Wolfgang and Krause, Dieter

Additively manufactured anatomical heart model for performance evaluation of aortic valve implants

Artikel in "Transactions on Additive Manufacturing Meets Medicine", vol. 2, Nr. 1, 2020

Abstract:

BibTeX:
@article{kuhl2020additively,
author = {Kuhl and Juliane and Mendoza Ponce and Pablo Daniel and Krautschneider and Wolfgang and Krause and Dieter},
title = {{A}dditively manufactured anatomical heart model for performance evaluation of aortic valve implants},
year = {2020},
month = {09},
journal = {Transactions on Additive Manufacturing Meets Medicine},
number = {1},
volume = {2} }

[BibTeX]
Pablo Mendoza Ponce, Gayas Sayed, Lait Abu Saleh, Wolfgang H. Krautschneider and Matthias Kuhl

A 1.9 nW Timer and Clock Generation Unit for Low Data-Rate Implantable Medical Devices

In Tagungsband "LASCAS 2020 - 11th IEEE Latin American Symposium on Circuits and Systems" der IEEE, 2020
San José, Costa Rica, 25-28 February 2020

Abstract:
This work presents a thyristor-based low power timer for wake up control of implantable monitoring devices, as well as a clock generation unit based on said approach. By using CMOS thyristors as delay elements in a ring oscillator, major drawbacks of conventional ring oscillators, such as a high stage count of inverters and capacitors with large currents flowing to ground during switching, can be overcome. This is particularly relevant for low frequency generation where these issues become even more critical in terms of power and area. Thyristors generate larger delays per stage while presenting a faster transition when switching between states, when compared to a typical CMOS inverter, an thus demand a smaller dynamic power. Timer, clock gating control and clock generation units were combined, implemented, and fabricated in 350nm CMOS technology. The timer is able to wake up the clocking system (and hence a digital control unit) every 32.45 s with a power budget of less than 2nW, while the clock generation unit produces a signal of 8.2 kHz.

BibTeX:
@inproceedings{MendozaPonce:LASCASTimer:2020,
author = {Pablo Mendoza Ponce and Gayas Sayed and Lait Abu Saleh and Wolfgang H. Krautschneider and Matthias Kuhl},
title = {{A} 1.9 n{W} {T}imer and {C}lock {G}eneration {U}nit for {L}ow {D}ata-{R}ate {I}mplantable {M}edical {D}evices},
year = {2020},
month = {02},
booktitle = {LASCAS 2020 - 11th IEEE Latin American Symposium on Circuits and Systems},
note = {San José, Costa Rica, 25-28 February 2020},
organization = {IEEE} }

[Abstract] [BibTeX]
Johan Solis-Arbustini, Pablo Mendoza-Ponce, Wolfgang H. Krautschneider and Matthias Kuhl

A 16-bits Pressure Sensing Interface Integrating a 460 fJ/conv Incremental Sigma Delta ADC for Medical Devices

In Tagungsband "LASCAS 2020 - 11th IEEE Latin American Symposium on Circuits and Systems" der IEEE, 2020
San José, Costa Rica, 25-28 February 2020

Abstract:
This work presents an incremental 2nd-order sigma delta using a single operational transconductance amplifier. This design provides a good trade-off between time conversion, high bit resolution, power consumption and area utilization for a pressure sensing reading interface. The modulator, designed in 180nm CMOS technology, has been optimized for low area utilization, occupying only 0:058mm2. Post-layout simulations were performed showing a resolution of 150 μV while consuming 120 μW and 460 fJ=conv. The system has a resolution of 16 bits, a bandwidth of 2kHz, an oversampling ratio of 512 and a sampling frequency of 2MHz.

BibTeX:
@inproceedings{Arbustini:LASCAS:2020,
author = {Johan Solis-Arbustini and Pablo Mendoza-Ponce and Wolfgang H. Krautschneider and Matthias Kuhl},
title = {{A} 16-bits {P}ressure {S}ensing {I}nterface {I}ntegrating a 460 f{J}/conv {I}ncremental {S}igma {D}elta {A}{D}{C} for {M}edical {D}evices},
year = {2020},
month = {02},
booktitle = {LASCAS 2020 - 11th IEEE Latin American Symposium on Circuits and Systems},
note = {San José, Costa Rica, 25-28 February 2020},
organization = {IEEE} }

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2019

Mendoza Ponce, Pablo and Abu Saleh, Lait and Krautschneider, Wolfgang and Kuhl, Matthias

3D-printing technology as a tool for medical implantable electronic devices

Artikel in "Transactions on Additive Manufacturing Meets Medicine", p. Vol 1 (2019): Trans. AMMM--, 2019

Abstract:
Medical implantable electronic devices (IMD) are of great use to research and in the treatment of various health conditions. 3D printing technology is proving to revolutionize multiple industries, including IMDs, by allowing rapid research, development and production. This paper presents how 3D printing technology was utilized during the modeling, prototyping and fabrication process of the first version of an implantable device intended for interstitial pressure monitoring.

BibTeX:
@article{https://doi.org/10.18416/ammm.2019.1909s02t03,
author = {Mendoza Ponce and Pablo and Abu Saleh and Lait and Krautschneider and Wolfgang and Kuhl and Matthias},
title = {3{D}-printing technology as a tool for medical implantable electronic devices},
year = {2019},
month = {11},
journal = {Transactions on Additive Manufacturing Meets Medicine},
pages = {Vol 1 (2019): Trans. AMMM--} }

[Abstract] [BibTeX] [DOI]
Christian Adam, Michael H. Teyfel and Dietmar Schroeder

Analog-to-Probability Conversion - Efficient Extraction of Information Based on Stochastic Signal Models

In Tagungsband "Progress in Industrial Mathematics at ECMI 2018", Verlag Springer International Publishing (Cham), 2019, p. 583--587, Herausgeber Faragó I., Izsák F., Simon P.
The 20th European Conference on Mathematics for Industry, Budapest, Ungary, 18-22 June 2018

Abstract:
Analog-to-probability conversion is introduced as a new concept for efficient parameter extraction from analog signals that can be described by nonlinear models. The current state of information about these parameters is represented by a multivariate probability distribution. Only a digital-to-analog converter and a comparator are required as acquisition hardware. The introduced approach reduces the number of comparisons to be done by the hardware and therefore the total energy consumption. As a proof of concept the algorithm is implemented on a system-on-chip and compared to a nonlinear least squares approach.

BibTeX:
@inproceedings{Adam:ECMI_APC:2019,
author = {Christian Adam and Michael H. Teyfel and Dietmar Schroeder},
title = {{A}nalog-to-{P}robability {C}onversion - {E}fficient {E}xtraction of {I}nformation {B}ased on {S}tochastic {S}ignal {M}odels},
year = {2019},
month = {11},
booktitle = {Progress in Industrial Mathematics at ECMI 2018},
address = {Cham},
editor = {Faragó I., Izsák F., Simon P.},
note = {The 20th European Conference on Mathematics for Industry, Budapest, Ungary, 18-22 June 2018},
pages = {583--587},
publisher = {Springer International Publishing} }

[Abstract] [BibTeX] [DOI]
M. Seifaei and D. Schillinger and M. Kuhl and M. Keller and U. Zschieschang and H. Klauk and Y. Manoli

Modified Bootstrap Switching Scheme for Organic Digital Integrated Circuits

Artikel in "IEEE Solid-State Circuits Letters", vol. 2, Nr. 10, p. 219-222, 2019

Abstract:
The design and implementation of a modified bootstrap switching circuit based on p-channel organic thin-film transistors and integrated thin-film resistors that addresses the lack of high-performance n-channel organic transistors is presented. Using the bootstrap technique, the fall time of the output stage is decreased by more than a factor of 10, resulting in a 10.39 times higher operating frequency for a load capacitance of 10 nF, and rail-to-rail output swing is achieved. A minimum-area inverter and a Schmitt-trigger-based inverter are presented that serve as references for comparison and as small-footprint alternatives to the bootstrap circuit. The dynamic performance of the proposed circuits is validated by comparing three different ring oscillator implementations.

BibTeX:
@article{8854293,
author = {M. Seifaei and D. Schillinger and M. Kuhl and M. Keller and U. Zschieschang and H. Klauk and Y. Manoli},
title = {{M}odified {B}ootstrap {S}witching {S}cheme for {O}rganic {D}igital {I}ntegrated {C}ircuits},
year = {2019},
month = {10},
journal = {IEEE Solid-State Circuits Letters},
number = {10},
pages = {219-222},
volume = {2} }

[Abstract] [BibTeX] [DOI]
P. Mendoza-Ponce and G. Sayed and L. A. Saleh and W. H. Krautschneider and M. Kuhl

A Pressure Sensor with 0.30 mmHg Resolution incorporating a 4.19 pJ/conv Thyristor-based Capacitance-to-Time Converter for Intra-Corporeal Pressure Monitoring Applications

In Tagungsband "2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)", 2019, p. 1-4
IEEE Biomedical Circuits and Systems Conference, Nara, Japan, 2019

Abstract:
This work presents a Capacitance-to-Digital Converter for in-vivo pressure monitoring in clinical scenarios. The developed system combines a Capacitance-to-Time Converter (CTC) and a Time-to-Digital Converter (TDC), of which the CTC presents a novel architecture based on CMOS Thyristor elements with a power consumption of only 2.99 µW. The interface was implemented in a 350 nm CMOS technology and tested in combination with a commercially available capacitive pressure transducer. The Capacitance-to-Time Converter unit achieves an average pressure resolution of 0.30 mmHg while consuming 4.19 pJ/conv.

BibTeX:
@inproceedings{8919042,
author = {P. Mendoza-Ponce and G. Sayed and L. A. Saleh and W. H. Krautschneider and M. Kuhl},
title = {{A} {P}ressure {S}ensor with 0.30 mm{H}g {R}esolution incorporating a 4.19 p{J}/conv {T}hyristor-based {C}apacitance-to-{T}ime {C}onverter for {I}ntra-{C}orporeal {P}ressure {M}onitoring {A}pplications},
year = {2019},
month = {10},
booktitle = {2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)},
note = {IEEE Biomedical Circuits and Systems Conference, Nara, Japan, 2019},
pages = {1-4} }

[Abstract] [BibTeX] [DOI]
Butz, Natalie and Kuhl, Matthias and Manoli, Yiannos

Charge Balancing Circuit, Stimulator Circuit and Method for Charge Balancing

apr 2019
US Patent App. 16/217,432

Abstract:

BibTeX:
@misc{butz2019charge,
author = {Butz and Natalie and Kuhl and Matthias and Manoli and Yiannos},
title = {{C}harge {B}alancing {C}ircuit, {S}timulator {C}ircuit and {M}ethod for {C}harge {B}alancing},
year = {2019},
month = {04},
note = {US Patent App. 16/217,432} }

[BibTeX]
Kuhl, Matthias and Manoli, Yiannos and Plachta, Dennis and Stieglitz, Thomas and Cota, Oscar

Digital biopotential acquisition system having 8 channels

Verlag Google Patents, feb 2019
US Patent App. 16/078,541

Abstract:

BibTeX:
@misc{kuhl2019digital,
author = {Kuhl and Matthias and Manoli and Yiannos and Plachta and Dennis and Stieglitz and Thomas and Cota and Oscar},
title = {{D}igital biopotential acquisition system having 8 channels},
year = {2019},
month = {02},
note = {US Patent App. 16/078,541},
publisher = {Google Patents} }

[BibTeX]

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